TY  - JOUR
PY  - 2014//
TI  - Transgenerational effects of binge drinking in a primate model: implications for human health
JO  - Fertility and sterility
A1  - VandeVoort, Catherine A.
A1  - Grimsrud, Kristin N.
A1  - Midic, Uros
A1  - Mtango, Namdori
A1  - Latham, Keith E.
SP  - 560
EP  - 569
VL  - 103
IS  - 2
N2  - OBJECTIVE: To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development. <br><br>DESIGN: Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating. SETTING: National primate research center. ANIMAL(S): Adult female rhesus monkeys. INTERVENTION(S): Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified. MAIN OUTCOME MEASURE(S): Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate. RESULT(S): Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased. <br><br>CONCLUSION(S): This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.<p />  <p>Language: en</p>
LA  - en
SN  - 0015-0282
UR  - http://dx.doi.org/10.1016/j.fertnstert.2014.10.051
ID  - ref1
ER  -