TY  - JOUR
PY  - 2014//
TI  - Interactions between traumatic brain injury and frontotemporal degeneration
JO  - Dementia and geriatric cognitive disorders
A1  - Deutsch, Mariel B.
A1  - Mendez, Mario F.
A1  - Teng, Edmond
SP  - 143
EP  - 153
VL  - 39
IS  - 3-4
N2  - BACKGROUND/AIMS: Prior work in smaller cohorts suggests that traumatic brain injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We sought to confirm and extend these results using the National Alzheimer's Coordinating Center Uniform Data Set. <br><br>METHODS: We compared the TBI prevalence between FTD subjects and matched normal controls. Indices of cognitive, behavioral, functional, and global dementia severity were compared between FTD subjects with and without prior TBI. <br><br>RESULTS: Remote TBI with extended loss of consciousness (TBI-ext) was more common in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With TBI-ext, less functional and global impairment was seen in the behavioral variant of FTD, but more behavioral pathology was seen in the semantic variant. <br><br>CONCLUSION: TBI may increase the FTD risk and influence clinical symptomatology and severity in FTD subtypes. © 2014 S. Karger AG, Basel.<p />  <p>Language: en</p>
LA  - en
SN  - 1420-8008
UR  - http://dx.doi.org/10.1159/000369787
ID  - ref1
ER  -