TY  - JOUR
PY  - 2015//
TI  - Clinical and analytical toxicology of opiate, cocaine and amphetamine
JO  - Annales de Biologie Clinique
A1  - Feliu, Catherine
A1  - Fouley, Aurélie
A1  - Millart, Hervé
A1  - Gozalo, Claire
A1  - Marty, Hélène
A1  - Djerada, Zoubir
SP  - 54
EP  - 69
VL  - 73
IS  - 1
N2  - In several circumstances, determination and quantification of illicit drugs in biological fluids are determinant. Contexts are varied such as driving under influence, traffic accident, clinical and forensic toxicology, doping analysis, chemical submission. Whole blood is the favoured matrix for the quantification of illicit drugs. Gas chromatography coupled with mass spectrometry (GC-MS) is the gold standard for these analyses. All methods developed must be at least equivalent to gas chromatography coupled with a mass spectrometer. Nowadays, new technologies are available to biologists and clinicians: liquid chromatography coupled with a mass spectrometry (LC/MS) or coupled with a tandem mass spectrometer (LC/MS/MS). The aim of this paper is to describe the state of the art regarding techniques of confirmation by mass spectrometry used for quantification of conventional drugs except cannabis.<p />  <p>Language: en</p>
LA  - en
SN  - 0003-3898
UR  - http://dx.doi.org/10.1684/abc.2014.1009
ID  - ref1
ER  -