TY  - JOUR
PY  - 2015//
TI  - Parameters of bone health and fracture risk in older female fall victims: what do they tell us?
JO  - Zeitschrift fur Gerontologie
A1  - Thaler, Heinrich W.
A1  - Oudshoorn, Christian
A1  - Hartholt, Klaas A.
A1  - van der Cammen, Tischa J. M.
SP  - 539
EP  - 542
VL  - 48
IS  - 6
N2  - INTRODUCTION: A common and severe osteoporotic type fracture in older women is a hip fracture. It is not clear whether bone turnover parameters measured in blood can be a useful tool to predict fracture risk in older persons. The aim of the current study was to assess the association between serum vitamin D (25OHD) levels, parathyroid hormone (PTH), total osteocalcin, carboxy-terminal collagen crosslinks (CTX) and hip fractures in older fallers. MATERIAL AND METHODS: A single centre, prospective cohort study of bone parameters was carried out in 400 female patients aged > 70 years including 200 with a hip fracture and 200 without fractures, admitted after a fall between January 2005 and December 2007. <br><br>RESULTS: Serum total osteocalcin levels were significantly lower in the fracture group compared to the non-fracture group (20.4 ng/ml vs 26.1 ng/ml, respectively, p = 0.01). This finding remained significant after exclusion of the patients on bisphosphonates (p = 0.003). There were no significant differences in 25OHD, PTH or CTX levels between the two groups. <br><br>CONCLUSION: In the current study there was an association between the presence of a hip fracture and lower total serum osteocalcin concentrations. This could be indicative of low bone turnover osteoporosis in these women. An association for other bone turnover markers was lacking.<p />  <p>Language: en</p>
LA  - en
SN  - 0044-281X
UR  - http://dx.doi.org/10.1007/s00391-014-0843-2
ID  - ref1
ER  -