TY  - JOUR
PY  - 2015//
TI  - Changes in gut hormones and leptin in military personnel during operational deployment in Afghanistan
JO  - Obesity
A1  - Hill, Neil E.
A1  - Fallowfield, Joanne L.
A1  - Delves, Simon K.
A1  - Ardley, Christian
A1  - Stacey, Michael
A1  - Ghatei, Mohammad
A1  - Bloom, Stephen R.
A1  - Frost, Gary
A1  - Brett, Stephen J.
A1  - Wilson, Duncan R.
A1  - Murphy, Kevin G.
SP  - 608
EP  - 614
VL  - 23
IS  - 3
N2  - OBJECTIVE: Understanding the mechanisms that drive weight loss in a lean population may elucidate systems that regulate normal energy homeostasis. This prospective study of British military volunteers investigated the effects of a 6-month deployment to Afghanistan on energy balance and circulating concentrations of specific appetite-regulating hormones. <br><br>METHODS: Measurements were obtained twice in the UK (during the Pre-deployment period) and once in Afghanistan, at Mid-deployment. Body mass, body composition, food intake, and appetite-regulatory hormones (leptin, active and total ghrelin, PYY, PP, GLP-1) were measured. <br><br>RESULTS: Repeated measures analysis of 105 volunteers showed body mass decreased by 4.9% ± 3.7% (P < 0.0001) during the first half of the deployment. Leptin concentrations were significantly correlated with percentage body fat at each time point. The reduction in percentage body fat between Pre-deployment and Mid-deployment was 8.6%, with a corresponding 48% decrease in mean circulating leptin. Pre-deployment leptin and total and active ghrelin levels correlated with subsequent change in body mass; however. no changes were observed in the anorectic gut hormones GLP-1, PP, or PYY. <br><br>CONCLUSIONS: These data suggest that changes in appetite-regulating hormones in front line military personnel occur in response to, but do not drive, reductions in body mass.<p />  <p>Language: en</p>
LA  - en
SN  - 1930-7381
UR  - http://dx.doi.org/10.1002/oby.21000
ID  - ref1
ER  -