TY  - JOUR
PY  - 2015//
TI  - A fatal intoxication with phenazone (antipyrine)
JO  - Forensic science international
A1  - Karinen, Ritva
A1  - Høiseth, Gudrun
A1  - Svendsen, Kristin Opsal
A1  - Rogde, Sidsel
A1  - Vindenes, Vigdis
SP  - e13
EP  - 5
VL  - 248
IS  - 
N2  - Phenazone is a non-opioid analgesic used to treat acute mild to moderate pain, and is considered to be a safe drug. It is most often sold as a nonprescription/over-the-counter drug. Very few fatalities due to phenazone overdoses are reported in the literature. We present a case where a man in his early sixties was found dead in his home in the bottom of a staircase, the scene suggesting that death might have been caused by blunt force injury. However, in spite of the apparently dramatic scene, the gross findings at autopsy did not reveal lethal injuries. Whole blood from the femoral vein was collected during autopsy and screened for drugs of abuse and medicinal drugs. The only toxicological findings were a very high concentration of phenazone (280mg/L) and a high therapeutic concentration of caffeine (34mg/L). An UPLC-MS/MS method was used for quantification of the drugs.<p />  <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/j.forsciint.2015.01.001
ID  - ref1
ER  -