TY  - JOUR
PY  - 2015//
TI  - Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence
JO  - Addictive behaviors
A1  - Roten, Amanda
A1  - Baker, Nathaniel L.
A1  - Gray, Kevin M.
SP  - 119
EP  - 123
VL  - 45C
IS  - 
N2  - BACKGROUND: Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance. <br><br>METHODS: This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery. <br><br>RESULTS: Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores. <br><br>CONCLUSIONS: These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-4603
UR  - http://dx.doi.org/10.1016/j.addbeh.2015.01.013
ID  - ref1
ER  -