TY  - JOUR
PY  - 2015//
TI  - Risk factors for rapid cycling in bipolar disorder
JO  - Bipolar disorders
A1  - Valentí, Marc
A1  - Pacchiarotti, Isabella
A1  - Undurraga, Juan
A1  - Bonnín, C. del Mar
A1  - Popovic, Dina
A1  - Goikolea, José M.
A1  - Torrent, Carla
A1  - Hidalgo-Mazzei, Diego
A1  - Colom, Francesc
A1  - Vieta, Eduard
SP  - 549
EP  - 559
VL  - 17
IS  - 5
N2  - OBJECTIVES: The aim of this study was to investigate the clinical factors associated with the development of rapid cycling, as well as to elucidate the role of antidepressants. <br><br>METHODS: The present study (NCT01503489) is a prospective, naturalistic cohort study conducted in a sample of 289 patients diagnosed with bipolar disorder followed and treated for up to 14 years. The patients were divided into two groups on the basis of the development of a rapid cycling course (n = 48) or no development of such a course (n = 241), and compared regarding sociodemographic, clinical, and outcome variables. <br><br>RESULTS: Among the 289 patients, 48 (16.6%) developed a rapid cycling course during the follow-up. Several differences were found between the two groups, but after performing Cox regression analysis, only atypical depressive symptoms (p = 0.001), age at onset (p = 0.015), and number of suicide attempts (p = 0.030) persisted as significantly associated with the development of a rapid cycling course. <br><br>CONCLUSIONS: The development of rapid cycling during the course of bipolar disorder is associated with a tendency to chronicity, with a poorer outcome, and with atypical depressive symptomatology. Our study also suggests that the development of rapid cycling is associated with a higher use of antidepressants.<p />  <p>Language: en</p>
LA  - en
SN  - 1398-5647
UR  - http://dx.doi.org/10.1111/bdi.12288
ID  - ref1
ER  -