TY  - JOUR
PY  - 2015//
TI  - Separate and interactive contributions of weak inhibitory control and threat sensitivity to prediction of suicide risk
JO  - Psychiatry research
A1  - Venables, Noah C.
A1  - Sellbom, Martin
A1  - Sourander, Andre
A1  - Kendler, Kenneth S.
A1  - Joiner, Thomas E.
A1  - Drislane, Laura E.
A1  - Sillanmaki, Lauri
A1  - Elonheimo, Henrik
A1  - Parkkola, Kai
A1  - Multimaki, Petteri
A1  - Patrick, Christopher J.
SP  - 461
EP  - 466
VL  - 226
IS  - 2-3
N2  - Biobehavioral dispositions can serve as valuable referents for biologically oriented research on core processes with relevance to many psychiatric conditions. The present study examined two such dispositional variables-weak response inhibition (or disinhibition; INH-) and threat sensitivity (or fearfulness; THT+)-as predictors of the serious transdiagnostic problem of suicide risk in two samples: male and female outpatients from a U.S. clinic (N=1078), and a population-based male military cohort from Finland (N=3855). INH- and THT+ were operationalized through scores on scale measures of disinhibition and fear/fearlessness, known to be related to DSM-defined clinical conditions and brain biomarkers. Suicide risk was assessed by clinician ratings (clinic sample) and questionnaires (both samples). Across samples and alternative suicide indices, INH- and THT+ each contributed uniquely to prediction of suicide risk-beyond internalizing and externalizing problems in the case of the clinic sample where diagnostic data were available. Further, in both samples, INH- and THT+ interactively predicted suicide risk, with individuals scoring concurrently high on both dispositions exhibiting markedly augmented risk. <br><br>FINDINGS demonstrate that dispositional constructs of INH- and THT+ are predictive of suicide risk, and hold potential as referents for biological research on suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2015.01.018
ID  - ref1
ER  -