TY  - JOUR
PY  - 2015//
TI  - Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort
JO  - Occupational and environmental medicine
A1  - Brouwer, Maartje
A1  - Koeman, Tom
A1  - van den Brandt, Piet A.
A1  - Kromhout, Hans
A1  - Schouten, Leo J.
A1  - Peters, Susan
A1  - Huss, Anke
A1  - Vermeulen, Roel
SP  - 448
EP  - 455
VL  - 72
IS  - 6
N2  - OBJECTIVES: We investigated the association between six occupational exposures (ie, pesticides, solvents, metals, diesel motor emissions (DME), extremely low frequency magnetic fields (ELF-MF) and electric shocks) and Parkinson's disease (PD) mortality in a large population-based prospective cohort study. <br><br>METHODS: The Netherlands Cohort Study on diet and cancer enrolled 58 279 men and 62 573 women aged 55-69 years in 1986. Participants were followed up for cause-specific mortality over 17.3 years, until December 2003, resulting in 402 male and 207 female PD deaths. Following a case-cohort design, a subcohort of 5 000 participants was randomly sampled from the complete cohort. Information on occupational history and potential confounders was collected at baseline. Job-exposure matrices were applied to assign occupational exposures. Associations with PD mortality were evaluated using Cox regression. <br><br>RESULTS: Among men, elevated HRs were observed for exposure to pesticides (eg, ever high exposed, HR 1.27, 95% CI 0.86 to 1.88) and ever high exposed to ELF-MF (HR 1.54, 95% CI 1.00 to 2.36). No association with exposure duration or trend in cumulative exposure was observed for any of the occupational exposures. <br><br>RESULTS among women were unstable due to small numbers of high-exposed women. <br><br>CONCLUSIONS: Associations with PD mortality were observed for occupational exposure to pesticides and ELF-MF. However, the weight given to these findings is limited by the absence of a monotonic trend with either duration or cumulative exposure. No associations were found between PD mortality and occupational exposure to solvents, metals, DME or electric shocks.<p />  <p>Language: en</p>
LA  - en
SN  - 1351-0711
UR  - http://dx.doi.org/10.1136/oemed-2014-102209
ID  - ref1
ER  -