TY  - JOUR
PY  - 2015//
TI  - Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders
JO  - World journal of biological psychiatry
A1  - Karanović, Jelena
A1  - Šviković, Saša
A1  - Pantović, Maja
A1  - Durica, Svetlana
A1  - Brajušković, Goran
A1  - Damjanović, Aleksandar
A1  - Jovanović, Vladimir
A1  - Ivković, Maja
A1  - Romac, Stanka
A1  - Savić Pavićević, Dušanka
SP  - 261
EP  - 271
VL  - 16
IS  - 4
N2  - OBJECTIVES. Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability. <br><br>METHODS. Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory-Self Report and List of Threatening Experiences Questionnaire, respectively. Selected ADAR and ADARB1 tag-variants, and HTR2C rs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors. <br><br>RESULTS. ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse. <br><br>CONCLUSIONS. SA vulnerability in psychiatric patients is related to the joint effect of ADARB1 and HTR2C variants, the existing mood disorder and the cumulative exposures to a various childhood and recent stressful experiences.<p />  <p>Language: en</p>
LA  - en
SN  - 1562-2975
UR  - http://dx.doi.org/10.3109/15622975.2014.1000374
ID  - ref1
ER  -