TY  - JOUR
PY  - 2015//
TI  - Self-reported aggressiveness during treatment with levetiracetam correlates with depression
JO  - Epilepsy and behavior
A1  - Mula, Marco
A1  - Agrawal, Niruj
A1  - Mustafa, Zainab
A1  - Mohanalingham, Krithika
A1  - Cock, Hannah R.
A1  - Lozsadi, Dora A.
A1  - von Oertzen, Tim J.
SP  - 64
EP  - 67
VL  - 45
IS  - 
N2  - PURPOSE: The purpose of this study was to identify clinical correlates of self-reported aggressiveness (SRA) in patients with epilepsy treated with levetiracetam (LEV) with special reference to the role of depression. <br><br>METHODS: A consecutive sample of adult outpatients with epilepsy was assessed with the Neurological Disorder Depression Inventory for Epilepsy, the Adverse Event Profile (AEP), and the Emotional Thermometer. <br><br>RESULTS: From a total sample of 163 consecutive patients treated with LEV, SRA at any level (from rarely a problem to always) was associated with a 7-fold increased risk of being depressed (95% CI: 3.0-17.5; p<0.001). Self-reported aggressiveness was reported as "always" a problem by 9.8% of the patients. In these patients, apart from depression, SRA was associated with high AEP total scores (55.1 vs. 39.3; p<0.001) and polytherapy (43.8% vs. 19.8%; p=0.034). Anxiety scores were not elevated (4.9 vs. 3.6; p=0.183). <br><br>CONCLUSIONS: Self-reported aggressiveness during treatment with LEV is not an isolated symptom but is associated with depressed mood. Anxiety-mediated mechanisms do not seem to be involved.<p />  <p>Language: en</p>
LA  - en
SN  - 1525-5050
UR  - http://dx.doi.org/10.1016/j.yebeh.2015.03.018
ID  - ref1
ER  -