TY - JOUR
PY - 2015//
TI - Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis
JO - PLoS one
A1 - Darvishi, Nahid
A1 - Farhadi, Mehran
A1 - Haghtalab, Tahereh
A1 - Poorolajal, Jalal
SP - e0126870
EP - e0126870
VL - 10
IS - 5
N2 - BACKGROUND: Several original studies have investigated the effect of alcohol use disorder (AUD) on suicidal thought and behavior, but there are serious discrepancies across the studies. Thus, a systematic assessment of the association between AUD and suicide is required.
METHODS: We searched PubMed, Web of Science, and Scopus until February 2015. We also searched the Psycinfo web site and journals and contacted authors. We included observational (cohort, case-control, and cross-sectional) studies addressing the association between AUD and suicide. The exposure of interest was AUD. The primary outcomes were suicidal ideation, suicide attempt, and completed suicide. We assessed heterogeneity using Q-test and I2 statistic. We explored publication bias using the Egger's and Begg's tests and funnel plot. We meta-analyzed the data with the random-effects models. For each outcome we calculated the overall odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CI).
RESULTS: We included 31 out of 8548 retrieved studies, with 420,732 participants. There was a significant association between AUD and suicidal ideation (OR=1.86; 95% CI: 1.38, 2.35), suicide attempt (OR=3.13; 95% CI: 2.45, 3.81); and completed suicide (OR=2.59; 95% CI: 1.95, 3.23 and RR=1.74; 95% CI: 1.26, 2.21). There was a significant heterogeneity among the studies, but little concern to the presence of publication bias.
CONCLUSIONS: There is sufficient evidence that AUD significantly increases the risk of suicidal ideation, suicide attempt, and completed suicide. Therefore, AUD can be considered an important predictor of suicide and a great source of premature death. Language: en
LA - en
SN - 1932-6203
UR - http://dx.doi.org/10.1371/journal.pone.0126870
ID - ref1
ER -