TY  - JOUR
PY  - 2015//
TI  - Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation
JO  - Surgery
A1  - Kohama, Keisuke
A1  - Yamashita, Hayato
A1  - Aoyama-Ishikawa, Michiko
A1  - Takahashi, Toru
A1  - Billiar, Timothy R.
A1  - Nishimura, Takeshi
A1  - Kotani, Joji
A1  - Nakao, Atsunori
SP  - 399
EP  - 407
VL  - 158
IS  - 2
N2  - INTRODUCTION: Hemorrhagic shock followed by fluid resuscitation (HS/R) triggers an inflammatory response and causes pulmonary inflammation that can lead to acute lung injury (ALI). Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects. This study examined the effects of inhaled hydrogen on ALI caused by HS/R. <br><br>METHODS: Rats were subjected to hemorrhagic shock by withdrawing blood to lower blood pressure followed by resuscitation with shed blood and saline to restore blood pressure. After HS/R, the rats were maintained in a control gas of similar composition to room air or exposed to 1.3% hydrogen. <br><br>RESULTS: HS/R induced ALI, as demonstrated by significantly impaired gas exchange, congestion, edema, cellular infiltration, and hemorrhage in the lungs. Hydrogen inhalation mitigated lung injury after HS/R, as indicated by significantly improved gas exchange and reduced cellular infiltration and hemorrhage. Hydrogen inhalation did not affect hemodynamic status during HS/R. Exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R. Lipid peroxidation was reduced significantly in the presence of hydrogen, indicating antioxidant effects. <br><br>CONCLUSION: Hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades.<p />  <p>Language: en</p>
LA  - en
SN  - 0039-6060
UR  - http://dx.doi.org/10.1016/j.surg.2015.03.038
ID  - ref1
ER  -