TY  - JOUR
PY  - 2015//
TI  - Physical effort affects heatstroke thermoregulatory response and mortality in rats
JO  - Shock
A1  - Geng, Yan
A1  - Peng, Na
A1  - Li, Xing-Gui
A1  - Liu, Ya-Nan
A1  - Li, Bing-Lin
A1  - Peng, Li-Qiong
A1  - Ma, Qiang
A1  - Su, Lei
SP  - 149
EP  - 156
VL  - 44
IS  - 2
N2  - Animals suffering from heatstroke (HS) following physical effort may have different heat-related core temperature (Tc) responses compared with passive HS. In the present study, conscious and unrestrained rats were exposed to ambient temperature (Ta) of 39.5 ± 0.2°C with or without running (run-heated or rest-heated, respectively) until HS onset, which was defined as the systolic blood pressure (SBP) starting to drop. In comparison with rest-heated rats, run-heated rats had a significantly shorter latency of HS onset. Physical effort did not have significant influence on hyperthermia severity (43.3±0.2°C at rest-heated, and 43.4±0.2°C at run-heated), but it could significantly decrease the thermal load to develop HS (315.1±37.3°C[BULLET OPERATOR]min for rest-heated, and 133.5±21.4°C[BULLET OPERATOR]min for run-heated). Working component during heat exposure may contribute to a decreased survival rate of HS (46.9% at rest-heated, and 31.3% at run-heated). Impaired heat dissipation during recovery may be the responsible for relative poor survival of run-heated rats. In both groups, survival was affected by Tc,HS and thermal area. Hypothermia (Tc <35°C) developed after HS onset, with no significant difference in Tc,min between the rest-heated and run-heated groups. These thermoregulatory responses to HS after physical effort may provide insight into HS pathophysiology.<p />  <p>Language: en</p>
LA  - en
SN  - 1073-2322
UR  - http://dx.doi.org/10.1097/SHK.0000000000000387
ID  - ref1
ER  -