TY  - JOUR
PY  - 2015//
TI  - Serotonin and dopamine candidate gene variants and alcohol- and non-alcohol-related aggression
JO  - Alcohol and alcoholism
A1  - Preuss, Ulrich W.
A1  - Koller, Gabriele
A1  - Samochowiec, Agnieszka
A1  - Zill, Peter
A1  - Samochowiec, Jerzy
A1  - Kucharska-Mazur, Jolanta
A1  - Wong, Jessica
A1  - Soyka, Michael
SP  - 690
EP  - 699
VL  - 50
IS  - 6
N2  - AIMS: Aggressive and criminal traits have a complex genetic background which interacts with environmental factors. Alcohol intoxication has been related to lower thresholds of aggressive behaviors. In this association study of two independent samples, a number of candidate gene variants (5HT2A T102C, 5-HTTLPR, DRD Ins-141Del, DAT1 VNTR) were related to violent criminal behavior and alcohol-related aggressive traits. <br><br>METHOD: Treatment-seeking alcohol-dependent individuals (293 patients and 499 controls from Germany, 180 patients and 402 controls from Poland) underwent a Semi-Structured Assessment for the Genetics of Alcoholism interview which gathered information on alcohol-related violence and criminal behaviors, beside alcohol dependence characteristics. <br><br>RESULTS: Patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism, more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. No significant association between candidate gene variants and criminal behavior was detected. 5HTTLPR variant was related to one characteristic of alcohol-related violence. <br><br>CONCLUSIONS: With findings from genome-wide association studies linking aggression-related traits to second messenger systems, further studies are needed to determine the genetic underpinnings of non-alcohol and alcohol-related aggression.<p />  <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/10.1093/alcalc/agv057
ID  - ref1
ER  -