TY  - JOUR
PY  - 2014//
TI  - Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal
JO  - International journal of neuropsychopharmacology
A1  - Von Diemen, Lisia
A1  - Kapczinski, Flavio
A1  - Sordi, Anne Orgle
A1  - de Magalhães Narvaez, Joana Correa
A1  - Guimarães, Luciano Santos Pinto
A1  - Kessler, Felix Henrique Paim
A1  - Pfaffenseller, Bianca
A1  - de Aguiar, Bianca Wollenhaupt
A1  - de Moura Gubert, Carolina
A1  - Pechansky, Flavio
SP  - 33
EP  - 40
VL  - 17
IS  - 1
N2  - Recent reports suggest that brain-derived neurotrophic factor (BDNF) could be a biomarker for relapse, drug craving and withdrawal severity. In particular, elevated BDNF levels among former cocaine users have been associated with higher rates of relapse in 90 d. However, no data are available on BDNF levels at baseline and during crack cocaine withdrawal. This study evaluated BDNF among crack cocaine users during inpatient treatment, before and after withdrawal, vs. healthy controls. Clinical correlates with changes in BDNF levels were also assessed. Serum BDNF was evaluated in 49 male crack users on the first and last days of hospitalization and in 97 healthy controls. Serum BDNF was assayed using a sandwich ELISA kit. BDNF levels were significantly lower upon admission when compared to controls, even after adjustment for age, length of inpatient treatment, number of crack rocks used in the last 30 d, years of crack use and interaction between the latter two variables. At discharge, BDNF levels between patients and controls were similar. Number of crack rocks used in the last 30 d and years of crack use were inversely correlated with the outcome. Our findings show that BDNF levels increase during early crack cocaine withdrawal, at an inverse correlation with number of crack rocks used in the last 30 d and years of crack use.<p />  <p>Language: en</p>
LA  - en
SN  - 1461-1457
UR  - http://dx.doi.org/10.1017/S146114571300103X
ID  - ref1
ER  -