TY  - JOUR
PY  - 2015//
TI  - Twenty years of schizophrenia research in the Northern Finland Birth Cohort 1966: a systematic review
JO  - Schizophrenia research and treatment
A1  - Jääskeläinen, Erika
A1  - Haapea, Marianne
A1  - Rautio, Nina
A1  - Juola, Pauliina
A1  - Penttilä, Matti
A1  - Nordström, Tanja
A1  - Rissanen, Ina
A1  - Husa, Anja
A1  - Keskinen, Emmi
A1  - Marttila, Riikka
A1  - Filatova, Svetlana
A1  - Paaso, Tiina-Mari
A1  - Koivukangas, Jenni
A1  - Moilanen, Kristiina
A1  - Isohanni, Matti
A1  - Miettunen, Jouko
SP  - 524875
EP  - 524875
VL  - 2015
IS  - 
N2  - Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother's mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia.<p />  <p>Language: en</p>
LA  - en
SN  - 2090-2085
UR  - http://dx.doi.org/10.1155/2015/524875
ID  - ref1
ER  -