TY  - JOUR
PY  - 2015//
TI  - Juvenile traumatic brain injury increases alcohol consumption and reward in female mice
JO  - Journal of neurotrauma
A1  - Weil, Zachary
A1  - Karelina, Kate
A1  - Gaier, Kristopher R.
A1  - Corrigan, Timothy Ed
A1  - Corrigan, John D.
SP  - 895
EP  - 903
VL  - 33
IS  - 9
N2  - Traumatic brain injury (TBI) is inextricably and bidirectionally linked with alcohol use, as by some estimates intoxication is the direct or indirect cause of one-third to one-half of all TBI cases. Alcohol use following injury can reduce the efficacy of rehabilitation and increase the chances for additional injury. Finally, TBI itself may be a risk factor for the development of alcohol use disorders. Children who suffer TBIs have poorer life outcomes and more risk of substance abuse. We used a standardized closed head injury to model mild traumatic brain injuries. We found that mice injured during adolescence but not during adulthood exhibited much greater alcohol self-administration in adulthood. Further, this phenomenon was limited to female mice. Using behavioral testing, including conditioned place preference assays, we showed that early injuries increase the rewarding properties of alcohol. Environmental enrichment administered after injury reduced axonal degeneration and prevented the increase in drinking behavior. Additionally, brain derived neurotrophic factor gene expression, which was reduced by TBI, was normalized by environmental enrichment. Together these results suggest a novel model of alterations in reward circuitry following trauma during development.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2015.3953
ID  - ref1
ER  -