TY  - JOUR
PY  - 2015//
TI  - Neurotoxicity associated with exposure to 1-bromopropane in golf-club cleansing workers
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Wang, Te-Hao
A1  - Wu, Ming-Ling
A1  - Wu, Ya-Hsueh
A1  - Tsai, Wen-Jen
A1  - Lin, Kon-Ping
A1  - Wang, Chao-Lin
A1  - Yang, Chen-Chang
A1  - Deng, Jou-Fang
SP  - 823
EP  - 826
VL  - 53
IS  - 8
N2  - BACKGROUND: 1-Bromopropane (1-BP) is an alternative to ozone-depleting solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP is associated with adverse peripheral sensory, motor, and central nervous system (CNS) effects. We report our Health Hazard and Medical Evaluation of 6 patients with neurotoxicity associated with occupational exposure to 1-BP. Case series and environmental evaluation. Six workers, 1 male and 5 female, were exposed to high ambient 1-BP concentrations while employed in a golf club cleaning factory. 1-BP was identified in the bulk solvent sample used by the workers and confirmed the workers' daily occupational exposure to 1-BP for 3-10 months. The major presenting symptoms were tingling pain, soreness in lower extremities, and paresthesia. N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys), a 1-BP metabolite, was identified by LC/MS/MS in the urine (0.171-1.74 mg/g-Cr) of these workers 5-26 days following 1-BP exposure. <br><br>DISCUSSION AND CONCLUSION: An occupational outbreak of 1-BP poisoning occurred as a result of recurrent power outages, condenser, and exhaust fans malfunction, and inadequate personal protection. Occupational exposure to 1-BP may result in peripheral neuropathy as well as adverse CNS effects. Urine AcPrCys may be a specific biomarker for 1-BP exposure.<p />  <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.3109/15563650.2015.1064939
ID  - ref1
ER  -