TY  - JOUR
PY  - 2015//
TI  - Dissecting the cannabinergic control of behavior: the where matters
JO  - Bioessays
A1  - Busquets-Garcia, Arnau
A1  - Desprez, Tifany
A1  - Metna-Laurent, Mathilde
A1  - Bellocchio, Luigi
A1  - Marsicano, Giovanni
A1  - Soria-Gomez, Edgar
SP  - 1215
EP  - 1225
VL  - 37
IS  - 11
N2  - The endocannabinoid system is the target of the main psychoactive component of the plant Cannabis sativa, the Δ(9) -tetrahydrocannabinol (THC). This system is composed by the cannabinoid receptors, the endogenous ligands, and the enzymes involved in their metabolic processes, which works both centrally and peripherally to regulate a plethora of physiological functions. This review aims at explaining how the site-specific actions of the endocannabinoid system impact on memory and feeding behavior through the cannabinoid receptors 1 (CB1 R). Centrally, CB1 R is widely distributed in many brain regions, different cell types (e.g. neuronal or glial cells) and intracellular compartments (e.g. mitochondria). Interestingly, cellular and molecular effects are differentially mediated by CB1 R according to their cell-type localization (e.g. glutamatergic or GABAergic neurons). Thus, understanding the cellular and subcellular function of CB1 R will provide new insights and aid the design of new compounds in cannabinoid-based medicine.<p />  <p>Language: en</p>
LA  - en
SN  - 0265-9247
UR  - http://dx.doi.org/10.1002/bies.201500046
ID  - ref1
ER  -