TY  - JOUR
PY  - 2015//
TI  - Ethanol exposure and isolated traumatic brain injury
JO  - Journal of clinical neuroscience
A1  - Brennan, James H.
A1  - Bernard, Stephen
A1  - Cameron, Peter A.
A1  - Olaussen, Alexander
A1  - Fitzgerald, Mark C.
A1  - Rosenfeld, Jeffrey V.
A1  - Mitra, Biswadev
SP  - 1928
EP  - 1932
VL  - 22
IS  - 12
N2  - This study aims to investigate an association between ethanol exposure and in-hospital mortality among patients with isolated traumatic brain injury (iTBI). Ethanol exposure is associated with a substantially increased risk of sustaining an iTBI. However, once an iTBI has been sustained, it is unclear whether ethanol exposure is neuroprotective or harmful. We conducted a retrospective review of patients who presented between 2006 and 2012 and were entered into the Alfred Hospital trauma registry. The patients who presented with iTBI, as defined by a head abbreviated injury scale (AIS) score ⩾3 and all other body regions with AIS<3, and who had ethanol levels recorded on admission, were eligible for inclusion. The association between ethanol exposure as a continuous variable, and in-hospital mortality, was explored using multivariable logistic regression analysis. There were 1688 patients with iTBI who met the inclusion criteria, 577 (34.2%) of whom tested positive for ethanol. Ethanol exposure was not significantly associated with a change in the in-hospital mortality rate (adjusted odds ratio 1.01; 95% confidence interval 1.00-1.02; p=0.19). A substantial proportion of patients with iTBI were exposed to ethanol, but ethanol exposure was not independently associated with a change in mortality rate following iTBI. Any neuroprotection or harm from ethanol exposure was not conclusive, requiring further prospective trials.<p />  <p>Language: en</p>
LA  - en
SN  - 0967-5868
UR  - http://dx.doi.org/10.1016/j.jocn.2015.05.034
ID  - ref1
ER  -