TY  - JOUR
PY  - 2015//
TI  - Monoamine Oxidase A gene polymorphisms and self reported aggressive behaviour in a Pakistani ethnic group
JO  - JPMA: Journal of the Pakistan Medical Association
A1  - Shah, Syed Shoaib
A1  - Mohyuddin, Aisha
A1  - Colonna, Vincenza
A1  - Mehdi, Syed Qasim
A1  - Ayub, Qasim
SP  - 818
EP  - 824
VL  - 65
IS  - 8
N2  - OBJECTIVE: To investigate the association of monoamine oxidase Agene polymorphisms with aggression. <br><br>METHODS: The study was conducted in an ethnic community in Lahore, Pakistan, from August 2008 to December 2009 on the basis of data that was collected through a questionnaire between August 2004 and September 2005. It analysed 10 single nucleotide polymorphisms of monoamine oxidase A in unrelated males from the same ethnic background who were administered a Punjabi translation of the Buss and Perry aggression questionnaire. SPSS 13 was used for statistical analysis. <br><br>RESULTS: Of the total 133 haplotypes studied, 52(39%) were Haplotype A, 58(43.6%) B, 8(6%) C, 3(2.3%) D, 9(6.8%) E and 3(2.3%) F. The six haplotypes were analysed for association with scores of the four subscales of the aggression questionnaire and multivariate analysis of variance showed no significant differences (p>0.05 each) in the error variances of the total scores and scores for three of the sub-scales across the haplotypes. The variance was significantly different only for the anger sub-scale (p<0.05). <br><br>CONCLUSIONS: The association of an extended haplotype with low levels of self-reported aggression in this study should assist in characterisation of functional variants responsible for non-aggressive behaviour in male subjects.<p />  <p>Language: en</p>
LA  - en
SN  - 0030-9982
UR  - http://dx.doi.org/
ID  - ref1
ER  -