TY  - JOUR
PY  - 2015//
TI  - Antihypertensive use and recurrent falls in community-dwelling older adults: findings from the Health ABC Study
JO  - Journals of gerontology. Series A: Biological sciences and medical sciences
A1  - Marcum, Zachary A.
A1  - Perera, Subashan
A1  - Newman, Anne B.
A1  - Thorpe, Joshua M.
A1  - Switzer, Galen E.
A1  - Gray, Shelly L.
A1  - Simonsick, Eleanor M.
A1  - Shorr, Ronald I.
A1  - Bauer, Douglas C.
A1  - Castle, Nicholas G.
A1  - Studenski, Stephanie A.
A1  - Hanlon, Joseph T.
SP  - 1562
EP  - 1568
VL  - 70
IS  - 12
N2  - BACKGROUND: Despite wide-spread use of antihypertensives in older adults, the literature is unclear about their association with incident recurrent falls over time. <br><br>METHODS: Health, Aging and Body Composition study participants (n = 2,948) who were well functioning at baseline (1997) were followed to Year 7 (2004). The main outcome was recurrent falls (≥2) in the ensuing 12 months. Antihypertensive use was examined as: (a) any versus none, (b) long- versus short-term (≥2 vs <2 years), and by (c) summated standardized daily dose (SDD; 1 = maximum recommended daily dose for one antihypertensive), and (d) subclass. <br><br>RESULTS: Controlling for potential demographic, health status/behavior and access to care confounders, we found no increase in risk of recurrent falls in antihypertensive users compared to nonusers (adjusted odds ratio [AOR] = 1.13; 95% CI = 0.88-1.46), or those taking higher SDDs or for longer durations. Only those using a loop diuretic were found to have a modest increased risk of recurrent falls (AOR = 1.50; 95% CI = 1.11-2.03). <br><br>CONCLUSIONS: Antihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders. Loop diuretic use may be associated with recurrent falls and needs further study.<p />  <p>Language: en</p>
LA  - en
SN  - 1079-5006
UR  - http://dx.doi.org/10.1093/gerona/glv095
ID  - ref1
ER  -