TY  - JOUR
PY  - 2015//
TI  - Methodology and preliminary results from the neurobiology of late-life depression study
JO  - International psychogeriatrics / IPA
A1  - Steffens, David C.
A1  - Manning, Kevin J.
A1  - Wu, Rong
A1  - Grady, James J.
A1  - Fortinsky, Richard H.
A1  - Tennen, Howard A.
SP  - 1987
EP  - 1997
VL  - 27
IS  - 12
N2  - BACKGROUND: We sought to investigate the relationship between neuroticism and depression in an elderly cohort. In this paper, we describe the methods of an National Institute of Mental Health-NIMH-supported study and present findings among the cohort enrolled to date. <br><br>METHODS: We used the NEO Personality Inventory to assess neuroticism, and we employed several cognitive neuroscience-based measures to examine emotional control. <br><br>RESULTS: Compared with a group of 27 non-depressed older control subjects, 33 older depressed subjects scored higher on measures of state and trait anxiety and neuroticism. On our experimental neuroscience-based measures, depressed subjects endorsed more negative words compared with controls on an emotional characterization test. In addition, we found a significant group-by-congruency effect on an emotional interference test where subjects were asked to identify the face's emotional expression while ignoring the words "fear" or "happy" labeled across the face. <br><br>CONCLUSION: Thus, in this preliminary work, we found significant differences in measures of neuroticism and emotional controls among older adults with and without depression.<p />  <p>Language: en</p>
LA  - en
SN  - 1041-6102
UR  - http://dx.doi.org/10.1017/S1041610215001386
ID  - ref1
ER  -