TY - JOUR PY - 2015// TI - Measurement of postmortem 1,5-anhydroglucitol in vitreous humor for forensic diagnosis JO - Journal of forensic sciences A1 - Takata, Tomoyo A1 - Yamasaki, Yukie A1 - Kitao, Takashi A1 - Miyaishi, Satoru SP - S150 EP - 3 VL - 61 Suppl 1 IS - N2 - In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r(2) = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.

Language: en

LA - en SN - 0022-1198 UR - http://dx.doi.org/10.1111/1556-4029.12963 ID - ref1 ER -