TY  - JOUR
PY  - 2015//
TI  - Depression and suicide ideation in chronic hepatitis C patients untreated and treated with interferon: prevalence, prevention, and treatment
JO  - Annals of gastroenterology
A1  - Lucaciu, Laura A.
A1  - Dumitrascu, Dan L.
SP  - 440
EP  - 447
VL  - 28
IS  - 4
N2  - Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects. We aimed to review the available data on the depression and suicide in CHC patients receiving or not antiviral therapy based on interferon treatment. A PubMed search was performed, identifying relevant papers published between 1991 and January 2015 concerning major depressive disorders and suicidal risk in patients under interferon. A total of 21 relevant papers were retrieved. Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy. Suicide risk was analyzed in 7 of the reviewed articles, and case reports of attempted suicide were discussed. Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression.<p />  <p>Language: en</p>
LA  - en
SN  - 1108-7471
UR  - http://dx.doi.org/
ID  - ref1
ER  -