TY  - JOUR
PY  - 2015//
TI  - Depression is associated with poor prognosis in patients with chronic obstructive pulmonary disease - a systematic review
JO  - Danish medical journal
A1  - Salte, Kim
A1  - Titlestad, Ingrid
A1  - Halling, Anders
SP  - A5137
EP  - A5137
VL  - 62
IS  - 10
N2  - INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data. <br><br>METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with significant methodological faults were excluded. <br><br>RESULTS: A total of 22 cohort studies were included. Of these studies, 20 were prospective, one retrospective and one was a combined retro- and prospective study. There was a tendency for studies with more patients and higher methodological quality to show a positive correlation. Sixteen of the studies showed that depression was associated with increased mortality (relative risk (RR): 1.02-3.6) and more COPD exacerbations (RR: 1.3-7.0). <br><br>CONCLUSIONS: The results showed that not only is depression a debilitating disease on its own, it also predisposes to COPD exacerbations and increased mortality in patients with COPD. Depression in patients with COPD is under-diagnosed and undertreated, and a stronger focus on the clinical significance of depression as co-morbidity is warranted.<p />  <p>Language: en</p>
LA  - en
SN  - 2245-1919
UR  - http://dx.doi.org/
ID  - ref1
ER  -