TY  - JOUR
PY  - 2015//
TI  - Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England
JO  - Addiction
A1  - Pierce, Matthias
A1  - Bird, Sheila M.
A1  - Hickman, Matthew
A1  - Marsden, John
A1  - Dunn, Graham
A1  - Jones, Andrew
A1  - Millar, Tim
SP  - 298
EP  - 308
VL  - 111
IS  - 2
N2  - AIMS: To compare the change in illicit opioid users' risk of fatal drug-related poisoning (DRP) associated with opioid agonist pharmacotherapy (OAP) and psychological support, and investigate the modifying effect of patient characteristics, criminal justice system (CJS) referral, and treatment completion. <br><br>DESIGN: National data linkage cohort study of the English National Drug Treatment Monitoring System and the Office for National Statistics national mortality database. Data were analysed using survival methods. SETTING: All services in England that provide publicly-funded, structured, treatment for illicit opioid users. PARTICIPANTS: Adults treated for opioid dependence during April 2005 to March 2009: 151,983 individuals; 69% male; median age 32.6 with 442,950 person-years of observation. MEASUREMENTS: The outcome was fatal DRP occurring during periods in or out of treatment, with adjustment for age, gender, substances used, injecting status, and CJS referral. <br><br>FINDINGS: There were 1,499 DRP deaths (3.4 per 1,000 person-years, 95% CI 3.2-3.6). DRP risk increased while patients were not enrolled in any treatment (adjusted hazard ratio [aHR] 1.73, 95% CI 1.55-1.92). Risk when enrolled only in a psychological intervention was double that during OAP (aHR 2.07, 95% CI 1.75-2.46). The increased risk when out of treatment was greater for men (aHR 1.88, 95% CI 1.67-2.12), illicit drug injectors (aHR 2.27, 95% CI 1.97-2.62), and those reporting problematic alcohol use (aHR 2.37, 95% CI 1.90-2.98). <br><br>CONCLUSIONS: Patients who received only psychological support for opioid dependence in England appear to be at greater risk of fatal opioid poisoning than those who received opioid agonist pharmacotherapy.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.13193
ID  - ref1
ER  -