TY  - JOUR
PY  - 2015//
TI  - Association of brain-derived neurotrophic factor G196a and attempted suicide: a case-control study in rural China
JO  - Neuropsychobiology
A1  - Wang, Jin-Yu
A1  - Wang, Xin-Ting
A1  - Wang, Lin-Lin
A1  - Jia, Cun-xian
SP  - 91
EP  - 96
VL  - 72
IS  - 2
N2  - BACKGROUND: Suicide is an important public problem, the mechanism of which has not been clarified. Many studies have focused on the molecular, biological and genetic mechanisms of suicide. Brain-derived neurotrophic factor (BDNF) G196A is one of the most leading loci in recent studies, but the results are inconsistent. <br><br>METHODS: We conducted a 1:1 age- and sex-matched case-control study in rural areas of Shandong Province, China. A total of 365 pairs of cases and controls were finally recruited into our study. The adjusted odds ratios (AORs) of BDNF 196G/G and their 95% confidence intervals (CIs) were calculated by multivariate conditional logistic regression models. <br><br>RESULTS: No association between BDNF polymorphisms and attempted suicide was found in the overall population. However, the BDNF 196G/G genotype was significantly related to attempted suicide in the elderly population (AOR = 7.85, 95% CI: 1.12-54.90, p = 0.038), while the associations were not significant in young and middle-aged groups. <br><br>CONCLUSION: Our study suggests that the BDNF 196G/G genotype increases the risk of attempted suicide in elderly people.<p />  <p>Language: en</p>
LA  - en
SN  - 0302-282X
UR  - http://dx.doi.org/10.1159/000439352
ID  - ref1
ER  -