TY  - JOUR
PY  - 2015//
TI  - Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior
JO  - Psychiatric genetics
A1  - Sublette, M. Elizabeth
A1  - Vaquero, Concepción
A1  - Baca-Garcia, Enrique
A1  - Pachano, Gabriela
A1  - Huang, Yung-yu
A1  - Oquendo, Maria A.
A1  - Mann, J. John
SP  - 81
EP  - 86
VL  - 26
IS  - 2
N2  - Fatty acid desaturase genes (FADS1-FADS2) encode desaturases participating in the biosynthesis of long-chain polyunsaturated fatty acids. As long-chain polyunsaturated fatty acids are implicated in major depressive disorder (MDD) and suicide risk, and as both are partly heritable, we studied the association of FADS1-FADS2 polymorphisms with MDD (635 cases, 480 controls) and suicide attempt status (291 attempters, 344 MDD nonattempters). Eighteen FADS-related single-nucleotide polymorphisms were genotyped from Caucasians enrolled in Madrid (n=791) or New York City (n=324) and entered as predictors into logistic regression analyses with diagnostic group or suicide attempt history as outcomes and location and sex as covariates. No associations were observed between any single-nucleotide polymorphisms and diagnosis or attempt status. As statistical power was adequate, we conclude that FADS1-FADS2 genetic variants may not be a common determinant of MDD.<p />  <p>Language: en</p>
LA  - en
SN  - 0955-8829
UR  - http://dx.doi.org/10.1097/YPG.0000000000000111
ID  - ref1
ER  -