TY  - JOUR
PY  - 2015//
TI  - A preliminary prospective study of an escalation in 'maximum daily drinks', fronto-parietal circuitry and impulsivity-related domains in young adult drinkers
JO  - Neuropsychopharmacology
A1  - Worhunsky, Patrick D.
A1  - Dager, Alecia D.
A1  - Meda, Shashwath A.
A1  - Khadka, Sabin
A1  - Stevens, Michael C.
A1  - Austad, Carol S.
A1  - Raskin, Sarah A.
A1  - Tennen, Howard
A1  - Wood, Rebecca M.
A1  - Fallahi, Carolyn R.
A1  - Potenza, Marc N.
A1  - Pearlson, Godfrey D.
SP  - 1637
EP  - 1647
VL  - 41
IS  - 6
N2  - Excessive alcohol use in young adults is associated with greater impulsivity and neurobiological alterations in executive control systems. The maximum number of drinks consumed during drinking occasions ('MaxDrinks') represents a phenotype linked to vulnerability of alcohol use disorders, and an increase, or 'escalation', in MaxDrinks may be indicative of greater risk for problematic drinking. Thirty-six young adult drinkers performed a Go/No-Go task during fMRI, completed impulsivity-related assessments, and provided monthly reports of alcohol use during a 12-month follow-up period. Participants were characterized by MaxDrinks at baseline and after follow-up, identifying 18 escalating-drinkers and 18 constant-drinkers. Independent component analysis was used to investigate functional brain networks associated with response inhibition, and relationships with principal component analysis derived impulsivity-related domains were examined. Greater baseline MaxDrinks was associated with an average reduction in the engagement of a right-lateralized fronto-parietal functional network, while an escalation in MaxDrinks was associated with a greater difference in fronto-parietal engagement between successful inhibitions and error trials. Escalating-drinkers displayed greater impulsivity/compulsivity-related domain scores that were positively associated with fronto-parietal network engagement and change in MaxDrinks during follow-up. In young adults, an escalating MaxDrinks trajectory was prospectively associated with altered fronto-parietal control mechanisms and greater impulsivity/compulsivity scores. Continued longitudinal studies of MaxDrinks trajectories, functional network activity and impulsivity/compulsivity-related features may lend further insight into an intermediate phenotype vulnerable for alcohol use and addictive disorders.Neuropsychopharmacology accepted article preview online, 30 October 2015. doi:10.1038/npp.2015.332.<p />  <p>Language: en</p>
LA  - en
SN  - 0893-133X
UR  - http://dx.doi.org/10.1038/npp.2015.332
ID  - ref1
ER  -