TY  - JOUR
PY  - 2015//
TI  - The burden of disease attributable to cannabis use in Canada in 2012
JO  - Addiction
A1  - Imtiaz, Sameer
A1  - Shield, Kevin D.
A1  - Roerecke, Michael
A1  - Cheng, Joyce
A1  - Popova, Svetlana
A1  - Kurdyak, Paul
A1  - Fischer, Benedikt
A1  - Rehm, Jürgen
SP  - 653
EP  - 662
VL  - 111
IS  - 4
N2  - BACKGROUND AND AIMS: Cannabis use is associated with several adverse health effects. However, little is known about the cannabis-attributable burden of disease. This study quantified the age-, sex- and adverse health effect-specific cannabis-attributable (1) mortality, (2) years of life lost due to premature mortality (YLLs), (3) years of life lost due to disability (YLDs) and (4) disability-adjusted life years (DALYs) in Canada in 2012. <br><br>DESIGN: Epidemiological modeling SETTING: Canada PARTICIPANTS: Canadians aged ≥ 15 years in 2012 MEASUREMENTS: Using Comparative Risk Assessment methodology, cannabis-attributable fractions were computed using Canadian exposure data and risk relations from large studies or meta-analyses. Outcome data were obtained from Canadian databases and the World Health Organization. The 95% confidence Intervals (CIs) were computed using Monte Carlo methodology. <br><br>FINDINGS: Cannabis use was estimated to have caused 287 deaths (95% CI: 108, 609), 10,533 YLLs (95% CI: 4,760, 20,833), 55,813 YLDs (95% CI: 38,175, 74,094) and 66,346 DALYs (95% CI: 47,785, 87,207), based on causal impacts on cannabis use disorders, schizophrenia, lung cancer and road traffic injuries. Cannabis-attributable burden of disease was highest among young people, and males accounted for twice the burden than females. Cannabis use disorders were the most important single cause of the cannabis-attributable burden of disease. <br><br>CONCLUSIONS: The cannabis-attributable burden of disease in Canada in 2012 included 55,813 years of life lost due to disability, mainly caused by cannabis use disorders. Although the cannabis-attributable burden of disease was substantial, it was much lower compared with other commonly used legal and illegal substances. Moreover, the evidence base for cannabis-attributable harms was smaller.       Keywords: Cannabis impaired driving    This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.13237
ID  - ref1
ER  -