TY  - JOUR
PY  - 2015//
TI  - Obsessive-compulsive personality disorder: evidence for two dimensions
JO  - Depression and anxiety
A1  - Riddle, Mark A.
A1  - Maher, Brion S.
A1  - Wang, Ying
A1  - Grados, Marco
A1  - Bienvenu, O. Joseph
A1  - Goes, Fernando S.
A1  - Cullen, Bernadette A.
A1  - Murphy, Dennis L.
A1  - Rauch, Scott L.
A1  - Greenberg, Benjamin D.
A1  - Knowles, James A.
A1  - McCracken, James T.
A1  - Pinto, Anthony
A1  - Piacentini, John
A1  - Pauls, David L.
A1  - Rasmussen, Steven A.
A1  - Shugart, Yin Yao
A1  - Nestadt, Gerald
A1  - Samuels, Jack
SP  - 128
EP  - 135
VL  - 33
IS  - 2
N2  - BACKGROUND: To determine possible dimensions that underlie obsessive-compulsive personality disorder (OCPD) and to investigate their clinical correlates, familiality, and genetic linkage. <br><br>METHODS: Participants were selected from 844 adults assessed with the Structured Instrument for the Diagnosis of DSM-IV Personality Disorders (SIDP) in the OCD Collaborative Genetics Study (OCGS) that targeted families with obsessive-compulsive disorder (OCD) affected sibling pairs. We conducted an exploratory factor analysis, which included the eight SIDP-derived DSM-IV OCPD traits and the indecision trait from the DSM-III, assessed clinical correlates, and estimated sib-sib correlations to evaluate familiality of the factors. Using MERLIN and MINX, we performed genome-wide quantitative trait locus (QTL) linkage analysis to test for allele sharing among individuals. <br><br>RESULTS: Two factors were identified: Factor 1: order/control (perfectionism, excessive devotion to work, overconscientiousness, reluctance to delegate, and rigidity); and Factor 2: hoarding/indecision (inability to discard and indecisiveness). Factor 1 score was associated with poor insight, whereas Factor 2 score was associated with task incompletion. A significant sib-sib correlation was found for Factor 2 (rICC =.354, P <.0001) but not Factor 1 (rICC =.129, P =.084). The linkage findings were different for the two factors. When Factor 2 was analyzed as a quantitative trait, a strong signal was detected on chromosome 10 at marker d10s1221: KAC LOD = 2.83, P =.0002; and marker d10s1225: KAC LOD = 1.35, P =.006. <br><br>CONCLUSIONS: The results indicate two factors of OCPD, order/control and hoarding/indecision. The hoarding/indecision factor is familial and shows modest linkage to a region on chromosome 10.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.22452
ID  - ref1
ER  -