TY  - JOUR
PY  - 2015//
TI  - Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10
JO  - Drug and alcohol dependence
A1  - Moreira, Fernanda Pedrotti
A1  - Medeiros, João Ricardo Carvalho
A1  - Lhullier, Alfredo Cardoso
A1  - Souza, Luciano Dias de Mattos
A1  - Jansen, Karen
A1  - Portela, Luis Valmor
A1  - Lara, Diogo R.
A1  - Silva, Ricardo Azevedo da
A1  - Wiener, Carolina David
A1  - Oses, Jean Pierre
SP  - 181
EP  - 185
VL  - 158
IS  - 
N2  - BACKGROUND: Cocaine abuse is capable of activating the innate immune system in the CNS resulting in deregulation of homeostasis between pro and antiinflammatory cytokines. The aim of this study was to investigate serum levels of pro and antiinflammatory cytokines, IL-6 and IL-10 respectively, in cocaine users from a young population-based sample. <br><br>METHODS: This is a case-control study nested in a cross-sectional population-based survey, with individuals of 18 and 35 years old. Two groups were selected: 24 healthy controls and 12 subjects who reported cocaine use. Serum IL-6 and IL-10 were measured by ELISA using a commercial kit. <br><br>RESULTS: There was a statistically significant increase in IL-6 (p=0.037) and decrease in IL-10 (p=0.007) serum levels, between cocaine users and the control group. There was also an increase in the ratio IL-6/IL-10 (p=0.013) among cocaine users individuals, when compared to the control group. <br><br>CONCLUSIONS: Our results suggest that cocaine users showed an activation of the immune system when compared a control group, demonstrating a disruption in the balance of pro and antiinflammatory cytokines. Thus, peripheral cytokines may represent a putative biomarkers for cocaine users, contributing to the development of diagnosis and effective treatments.<p />  <p>Language: en</p>
LA  - en
SN  - 0376-8716
UR  - http://dx.doi.org/10.1016/j.drugalcdep.2015.11.024
ID  - ref1
ER  -