TY  - JOUR
PY  - 2015//
TI  - Sex-dependent depression-like behavior induced by respiratory administration of aluminum oxide nanoparticles
JO  - International journal of environmental research and public health
A1  - Zhang, Xin
A1  - Xu, Yan
A1  - Zhou, Lian
A1  - Zhang, Chengcheng
A1  - Meng, Qingtao
A1  - Wu, Shenshen
A1  - Wang, Shizhi
A1  - Ding, Zhen
A1  - Chen, Xiaodong
A1  - Li, Xiaobo
A1  - Chen, Rui
SP  - 15692
EP  - 15705
VL  - 12
IS  - 12
N2  - Ultrafine aluminum oxide, which are abundant in ambient and involved occupational environments, are associated with neurobehavioral alterations. However, few studies have focused on the effect of sex differences following exposure to environmental Al₂O₃ ultrafine particles. In the present study, male and female mice were exposed to Al₂O₃ nanoparticles (NPs) through a respiratory route. Only the female mice showed depression-like behavior. Although no obvious pathological changes were observed in mice brain tissues, the neurotransmitter and voltage-gated ion channel related gene expression, as well as the small molecule metabolites in the cerebral cortex, were differentially modulated between male and female mice. Both mental disorder-involved gene expression levels and metabolomics analysis results strongly suggested that glutamate pathways were implicated in sex differentiation induced by Al₂O₃ NPs. <br><br>RESULTS demonstrated the potential mechanism of environmental ultrafine particle-induced depression-like behavior and the importance of sex dimorphism in the toxic research of environmental chemicals.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-7827
UR  - http://dx.doi.org/10.3390/ijerph121215011
ID  - ref1
ER  -