TY  - JOUR
PY  - 2015//
TI  - Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder
JO  - Psychiatry research
A1  - Toda, Hiroyuki
A1  - Inoue, Takeshi
A1  - Tsunoda, Tomoya
A1  - Nakai, Yukiei
A1  - Tanichi, Masaaki
A1  - Tanaka, Teppei
A1  - Hashimoto, Naoki
A1  - Takaesu, Yoshikazu
A1  - Nakagawa, Shin
A1  - Kitaichi, Yuji
A1  - Boku, Shuken
A1  - Tanabe, Hajime
A1  - Nibuya, Masashi
A1  - Yoshino, Aihide
A1  - Kusumi, Ichiro
SP  - 142
EP  - 147
VL  - 236
IS  - 
N2  - Previous studies have shown that various factors, such as genetic and environmental factors, contribute to the development of major depressive disorder (MDD). The aim of this study is to clarify how multiple factors, including affective temperaments, childhood abuse and adult life events, are involved in the severity of depressive symptoms in MDD. A total of 98 participants with MDD were studied using the following self-administered questionnaire surveys: Patient Health Questionnaire-9 measuring the severity of depressive symptoms; Life Experiences Survey (LES) measuring negative and positive adult life events; Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego auto-questionnaire (TEMPS-A) measuring affective temperaments; and the Child Abuse and Trauma Scale (CATS) measuring childhood abuse. The data were analyzed using single and multiple regression analyses and structural equation modeling (SEM). The neglect score reported by CATS indirectly predicted the severity of depressive symptoms through affective temperaments measured by TEMPS-A in SEM. Four temperaments (depressive, cyclothymic, irritable, and anxious) directly predicted the severity of depressive symptoms. The negative change in the LES score also directly predicted severity. This study suggests that childhood abuse, especially neglect, indirectly increases the severity of depressive symptoms through increased scores of affective temperaments in MDD.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2015.12.016
ID  - ref1
ER  -