TY  - JOUR
PY  - 2015//
TI  - Snake venomics and antivenomics of Bothrops diporus, a medically important pitviper in Northeastern Argentina
JO  - Toxins (Basel)
A1  - Gay, Carolina
A1  - Sanz, Libia
A1  - Calvete, Juan J.
A1  - Pla, Davinia
SP  - e8010009
EP  - e8010009
VL  - 8
IS  - 1
N2  - Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families, being dominated by PI- and PIII-SVMPs, PLA₂ molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom.<p />  <p>Language: en</p>
LA  - en
SN  - 2072-6651
UR  - http://dx.doi.org/10.3390/toxins8010009
ID  - ref1
ER  -