TY  - JOUR
PY  - 2016//
TI  - Chronic traumatic encephalopathy: the neuropathological legacy of traumatic brain injury
JO  - Annual review of pathology
A1  - Hay, Jennifer
A1  - Johnson, Victoria E.
A1  - Smith, Douglas H.
A1  - Stewart, William
SP  - 21
EP  - 45
VL  - 11
IS  - 
N2  - Almost a century ago, the first clinical account of the punch-drunk syndrome emerged, describing chronic neurological and neuropsychiatric sequelae occurring in former boxers. Thereafter, throughout the twentieth century, further reports added to our understanding of the neuropathological consequences of a career in boxing, leading to descriptions of a distinct neurodegenerative pathology, termed dementia pugilistica. During the past decade, growing recognition of this pathology in autopsy studies of nonboxers who were exposed to repetitive, mild, traumatic brain injury, or to a single, moderate or severe traumatic brain injury, has led to an awareness that it is exposure to traumatic brain injury that carries with it a risk of this neurodegenerative disease, not the sport or the circumstance in which the injury is sustained. Furthermore, the neuropathology of the neurodegeneration that occurs after traumatic brain injury, now termed chronic traumatic encephalopathy, is acknowledged as being a complex, mixed, but distinctive, pathology, the detail of which is reviewed in this article. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease Volume 11 is March 24, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.<p />  <p>Language: en</p>
LA  - en
SN  - 1553-4006
UR  - http://dx.doi.org/10.1146/annurev-pathol-012615-044116
ID  - ref1
ER  -