TY  - JOUR
PY  - 2016//
TI  - Interaction of CD38 variant and chronic interpersonal stress prospectively predicts social anxiety and depression symptoms over 6 years
JO  - Clinical psychological science
A1  - Tabak, Benjamin A.
A1  - Vrshek-Schallhorn, Suzanne
A1  - Zinbarg, Richard E.
A1  - Prenoveau, Jason M.
A1  - Mineka, Susan
A1  - Redei, Eva E.
A1  - Adam, Emma K.
A1  - Craske, Michelle G.
SP  - 17
EP  - 27
VL  - 4
IS  - 1
N2  - Variation in the CD38 gene, which regulates secretion of the neuropeptide oxytocin, has been associated with several social phenotypes. Specifically, rs3796863 A allele carriers have demonstrated increased social sensitivity. In 400 older adolescents, we used trait-state-occasion modeling to investigate how rs3796863 genotype, baseline ratings of chronic interpersonal stress, and their gene-environment (G×E) interaction predicted trait social anxiety and depression symptoms over 6 years. We found significant G×E effects for CD38 A-carrier genotypes and chronic interpersonal stress at baseline predicting greater social anxiety and depression symptoms. A significant G×E effect of smaller magnitude was also found for C/C genotype and chronic interpersonal stress predicting greater depression; however, this effect was small compared with the main effect of chronic interpersonal stress. Thus, in the context of chronic interpersonal stress, heightened social sensitivity associated with the rs3796863 A allele may prospectively predict risk for social anxiety and (to a lesser extent) depression.<p />  <p>Language: en</p>
LA  - en
SN  - 2167-7026
UR  - http://dx.doi.org/10.1177/2167702615577470
ID  - ref1
ER  -