TY  - JOUR
PY  - 2016//
TI  - Mild concussion, but not moderate traumatic brain injury, is associated with long-term depression-like phenotype in mice
JO  - PLoS one
A1  - Bajwa, Nikita M.
A1  - Halavi, Shina
A1  - Hamer, Mary
A1  - Semple, Bridgette D.
A1  - Noble-Haeusslein, Linda J.
A1  - Baghchechi, Mohsen
A1  - Hiroto, Alex
A1  - Hartman, Richard E.
A1  - Obenaus, Andre
SP  - e0146886
EP  - e0146886
VL  - 11
IS  - 1
N2  - Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, and affective disorders. Our study focused on long-term behavioral deficits after repeated injury in which mice received either a single mild CHI (mCHI), a repeated mild CHI (rmCHI) consisting of one impact to each hemisphere separated by 3 days, or a moderate controlled cortical impact injury (CCI). Shams received only anesthesia. Behavioral tests were administered at 1, 3, 5, 7, and 90 days post-injury (dpi). CCI animals showed significant motor and sensory deficits in the early (1-7 dpi) and long-term (90 dpi) stages of testing. Interestingly, sensory and subtle motor deficits in rmCHI animals were found at 90 dpi. Most importantly, depression-like behaviors and social passiveness were observed in rmCHI animals at 90 dpi. These data suggest that mild concussive injuries lead to motor and sensory deficits and affective disorders that are not observed after moderate TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0146886
ID  - ref1
ER  -