TY  - JOUR
PY  - 2006//
TI  - Adverse effects in children after unintentional buprenorphine exposure
JO  - Pediatrics
A1  - Geib, Ann-Jeannette
A1  - Babu, Kavita
A1  - Ewald, Michele Burns
A1  - Boyer, Edward W.
SP  - 1746
EP  - 1751
VL  - 118
IS  - 4
N2  - Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on respiratory depression, all children required hospital admission and either opioid-antagonist therapy or mechanical ventilation. Results of routine urine toxicology screening for opioids were negative in all cases. Confirmatory testing was sent for 1 child and returned with a positive result. The increasing use of buprenorphine as a home-based therapy for opioid addiction in the United States raises public health concerns for the pediatric population.<p />  <p>Language: en</p>
LA  - en
SN  - 0031-4005
UR  - http://dx.doi.org/10.1542/peds.2006-0948
ID  - ref1
ER  -