TY  - JOUR
PY  - 2016//
TI  - The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders
JO  - Brain and behavior
A1  - Kristjansson, Sean
A1  - McCutcheon, Vivia V.
A1  - Agrawal, Arpana
A1  - Lynskey, Michael T.
A1  - Conroy, Elizabeth
A1  - Statham, Dixie J.
A1  - Madden, Pamela A. F.
A1  - Henders, Anjali K.
A1  - Todorov, Alexandre A.
A1  - Bucholz, Kathleen K.
A1  - Degenhardt, Louisa
A1  - Martin, Nicholas G.
A1  - Heath, Andrew C.
A1  - Nelson, Elliot C.
SP  - e00432
EP  - e00432
VL  - 6
IS  - 2
N2  - INTRODUCTION: Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations. <br><br>METHODS: We performed multigroup confirmatory factor analysis (CFA), separately by sex, using data from the Childhood Trauma (CT) Study's sample of twins and siblings (N = 2594) to derive three first-order factors (childhood physical abuse, childhood sexual abuse, and parental partner abuse) and, as hypothesized, one higher order, childhood trauma factor (CTF) representing a measure of their common variance. <br><br>RESULTS: CFA produced a good-fitting model in the CT Study; we replicated the model in the Comorbidity and Trauma (CAT) Study's sample (N = 1981) of opioid-dependent cases and controls. In both samples, first-order factors are moderately correlated (indicating they measure largely unique, but related constructs) and their loadings on the CTF suggest it provides a reasonable measure of their common variance. We examined the association of CTF score with risk for psychiatric and substance use disorders in these samples and the OZ-ALC GWAS sample (N = 1538) in which CT Study factor loadings were applied. We found that CTF scores are strongly associated with liability for psychiatric and substance use disorders in all three samples; estimates of risk are extremely consistent across samples. <br><br>CONCLUSIONS: The CTF is a continuous, robust measure that captures the common variance across forms of childhood trauma and provides a means to estimate shared liability while avoiding multicollinearity.<p />  <p>Language: en</p>
LA  - en
SN  - 2162-3279
UR  - http://dx.doi.org/10.1002/brb3.432
ID  - ref1
ER  -