TY  - JOUR
PY  - 2016//
TI  - Gun violence, African ancestry, and asthma: a case-control study in Puerto Rican children
JO  - Chest
A1  - Rosas-Salazar, Christian
A1  - Han, Yueh-Ying
A1  - Brehm, John M.
A1  - Forno, Erick
A1  - Acosta-Pérez, Edna
A1  - Cloutier, Michelle M.
A1  - Alvarez, Maria
A1  - Colón-Semidey, Angel
A1  - Canino, Glorisa
A1  - Celedon, Juan C.
SP  - 1436
EP  - 1444
VL  - 149
IS  - 6
N2  - BACKGROUND: Exposure to gun violence and African ancestry have been separately associated with increased risk of asthma in Puerto Rican children. <br><br>OBJECTIVE: To examine whether African ancestry and gun violence interact on asthma and total IgE in school-aged Puerto Rican children. <br><br>METHODS: Case-control study of 747 Puerto Rican children aged 9 to 14 years living in San Juan, Puerto Rico (n=472), and Hartford, Connecticut (n=275). Exposure to gun violence was defined as the child's report of hearing gunshots more than once, and the percentage of African ancestry was estimated using genome-wide genotypic data. Asthma was defined as parental report of physician-diagnosed asthma and wheeze in the previous year. Serum total IgE (IU/mL) was measured in study participants. Multivariate logistic and linear regression were used for the analysis of asthma and total IgE, respectively. <br><br>RESULTS: In multivariate analyses, there was a significant interaction between exposure to gun violence and African ancestry on asthma (P=0.001) and serum total IgE (P=0.04). Among children exposed to gun violence, each quartile increase in the percentage of African ancestry was associated with ∼45% higher odds of asthma (95% CI=1.15-1.84, P=0.002) and a ∼19% increment in total IgE (95% CI= 0.60-40.65, P=0.04). In contrast, there was no significant association between African ancestry and asthma or total IgE in children not exposed to gun violence. <br><br>CONCLUSION: Our results suggest that exposure to gun violence modifies the estimated effect of African ancestry on asthma and atopy in Puerto Rican children.<p />  <p>Language: en</p>
LA  - en
SN  - 0012-3692
UR  - http://dx.doi.org/10.1016/j.chest.2016.02.639
ID  - ref1
ER  -