TY  - JOUR
PY  - 2016//
TI  - Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations
JO  - Annals of the New York Academy of Sciences
A1  - Haouzi, Philippe
A1  - Sonobe, Takashi
A1  - Judenherc-Haouzi, Annick
SP  - 29
EP  - 40
VL  - 1374
IS  - 1
N2  - Hydrogen sulfide (H2 S) is a chemical hazard in the gas and farming industry. As it is easy to manufacture from common chemicals, it has also become a method of suicide. H2 S exerts its toxicity through its high affinity with metalloproteins, such as cytochrome c oxidase and possibly via its interactions with cysteine residues of various proteins. The latter was recently proposed to acutely alter ion channels with critical implications for cardiac and brain functions. Indeed, during severe H2 S intoxication, a coma, associated with a reduction in cardiac contractility, develops within minutes or even seconds leading to death by complete electromechanical dissociation of the heart. In addition, long-term neurological deficits can develop owing to the direct toxicity of H2 S on neurons combined with the consequences of a prolonged apnea and circulatory failure. Here, we review the challenges impeding efforts to offer an effective treatment against H2 S intoxication using agents that trap free H2 S, and present novel pharmacological approaches aimed at correcting some of the most harmful consequences of H2 S intoxication.<br><br>© 2016 New York Academy of Sciences.<p />  <p>Language: en</p>
LA  - en
SN  - 0077-8923
UR  - http://dx.doi.org/10.1111/nyas.13015
ID  - ref1
ER  -