TY  - JOUR
PY  - 2016//
TI  - Brain regions related to impulsivity mediate the effects of early adversity on antisocial behavior
JO  - Biological psychiatry
A1  - Mackey, Scott
A1  - Chaarani, Bader
A1  - Kan, Kees-Jan
A1  - Spechler, Philip A.
A1  - Orr, Catherine
A1  - Banaschewski, Tobias
A1  - Barker, Gareth
A1  - Bokde, Arun L. W.
A1  - Bromberg, Uli
A1  - Büchel, Christian
A1  - Cattrell, Anna
A1  - Conrod, Patricia J.
A1  - Desrivieres, Sylvane
A1  - Flor, Herta
A1  - Frouin, Vincent
A1  - Gallinat, Jürgen
A1  - Gowland, Penny
A1  - Heinz, Andreas
A1  - Ittermann, Bernd
A1  - Paillère Martinot, Marie-Laure
A1  - Artiges, Eric
A1  - Nees, Frauke
A1  - Papadopoulos-Orfanos, Dimitri
A1  - Poustka, Luise
A1  - Smolka, Michael N.
A1  - Jurk, Sarah
A1  - Walter, Henrik
A1  - Whelan, Robert
A1  - Schumann, Gunter
A1  - Althoff, Robert R.
A1  - Garavan, Hugh
SP  - 275
EP  - 282
VL  - 82
IS  - 4
N2  - BACKGROUND: Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood. <br><br>METHODS: Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use). <br><br>RESULTS: Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior. <br><br>CONCLUSIONS: Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.<br><br>Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2015.12.027
ID  - ref1
ER  -