TY  - JOUR
PY  - 2016//
TI  - Methylmercury and brain development: a review of recent literature
JO  - Journal of trace elements in medicine and biology
A1  - Antunes Dos Santos, Alessandra
A1  - Appel Hort, Mariana
A1  - Culbreth, Megan
A1  - López-Granero, Caridad
A1  - Farina, Marcelo
A1  - Rocha, João B. T.
A1  - Aschner, Michael
SP  - 99
EP  - 107
VL  - 38
IS  - 
N2  - Methylmercury (MeHg) is a potent environmental pollutant, which elicits significant toxicity in humans. The central nervous system (CNS) is the primary target of toxicity, and is particularly vulnerable during development. Maternal exposure to MeHg via consumption of fish and seafood can have irreversible effects on the neurobehavioral development of children, even in the absence of symptoms in the mother. It is well documented that developmental MeHg exposure may lead to neurological alterations, including cognitive and motor dysfunction. The neurotoxic effects of MeHg on the developing brain have been extensively studied. The mechanism of toxicity, however, is not fully understood. No single process can explain the multitude of effects observed in MeHg-induced neurotoxicity. This review summarizes the most current knowledge on the effects of MeHg during nervous system development considering both, in vitro and in vivo experimental models. Considerable attention was directed towards the role of glutamate and calcium dyshomeostasis, mitochondrial dysfunction, as well as the effects of MeHg on cytoskeletal components/regulators.<br><br>Copyright © 2016 Elsevier GmbH. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0946-672X
UR  - http://dx.doi.org/10.1016/j.jtemb.2016.03.001
ID  - ref1
ER  -