TY  - JOUR
PY  - 2016//
TI  - Vigilance in the laboratory predicts avoidance in the real world: a dimensional analysis of neural, behavioral, and ecological momentary data in anxious youth
JO  - Developmental cognitive neuroscience
A1  - Price, Rebecca B.
A1  - Allen, Kristy Benoit
A1  - Silk, Jennifer S.
A1  - Ladouceur, Cecile D.
A1  - Ryan, Neal D.
A1  - Dahl, Ronald E.
A1  - Forbes, Erika E.
A1  - Siegle, Greg J.
SP  - 128
EP  - 136
VL  - 19
IS  - 
N2  - Vigilance and avoidance of threat are observed in anxious adults during laboratory tasks, and are posited to have real-world clinical relevance, but data are mixed in anxious youth. We propose that vigilance-avoidance patterns will become evident in anxious youth through a focus on individual differences and real-world strategic avoidance. Decreased functional connectivity between the amygdala and prefrontal cortex (PFC) could play a mechanistic role in this link. 78 clinically anxious youth completed a dot-probe task to assess vigilance to threat while undergoing fMRI. Real-world avoidance was assessed using Ecological Momentary Assessment (EMA) of self-reported suppression and distraction during negative life events. Vigilance toward threat was positively associated with EMA distraction and suppression. Functional connectivity between a right amygdala seed region and dorsomedial and right dorsolateral PFC regions was inversely related to EMA distraction. Dorsolateral PFC-amygdalar connectivity statistically mediated the relationship between attentional vigilance and real-world distraction. <br><br>FINDINGS suggest anxious youth showing attentional vigilance toward threat are more likely to use suppression and distraction to regulate negative emotions. Reduced PFC control over limbic reactivity is a possible neural substrate of this pattern. These findings lend ecological validity to laboratory vigilance assessments and suggest PFC-amygdalar connectivity is a neural mechanism bridging laboratory and naturalistic contexts.<br><br>Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1878-9293
UR  - http://dx.doi.org/10.1016/j.dcn.2016.03.001
ID  - ref1
ER  -