TY  - JOUR
PY  - 2016//
TI  - Structural and functional connectivity in posttraumatic stress disorder: associations with FKBP5
JO  - Depression and anxiety
A1  - Fani, Negar
A1  - King, Tricia Z.
A1  - Shin, Jaemin
A1  - Srivastava, Amita
A1  - Brewster, Ryan C.
A1  - Jovanovic, Tanja
A1  - Bradley, Bekh
A1  - Ressler, Kerry J.
SP  - 300
EP  - 307
VL  - 33
IS  - 4
N2  - BACKGROUND: The integrity of connections between the hippocampus and the anterior cingulate cortex (ACC) is critical for adaptive cognitive and emotional processing; these connections may be compromised in posttraumatic stress disorder (PTSD). However, there is a lack of PTSD research that combines structural and functional connectivity data, and no studies have examined whether abnormal ACC-hippocampal connectivity is associated with genetic variability, particularly for polymorphisms of a gene that has been previously associated with PTSD, FKBP5. This was the goal of the present study. <br><br>METHODS: Fifty-four women with and without PTSD underwent diffusion tensor imaging and resting-state MRI. Probabilistic tractography was used to examine ACC-hippocampal structural connectivity; mean fractional anisotropy (FA) values were extracted from connectivity streamlines, which represent the cingulum bundle. Genotype data were collected for a single nucleotide polymorphism (SNP) of FKBP5, rs1360780. <br><br>RESULTS: Participants with PTSD demonstrated poorer structural connectivity (lower cingulum FA) compared to traumatized controls (F1, 50 = 6.77, P <.05). An interaction of FKBP5 genotype and diagnostic group was also observed (F1, 37 = 4.52, P =.04), indicating lower cingulum FA in carriers of two risk alleles for this SNP, compared to other diagnostic and genotype groups. Carriers of two FKBP5 risk alleles also demonstrated poorer hippocampus-ACC connectivity at rest (P <.05). When cingulum FA was used a regressor in a brain-wide, seed-based regression analysis, significant associations were found between the hippocampus and dorsal regions of the ACC (P <.05). <br><br>CONCLUSIONS: Individuals with PTSD demonstrated compromised structural connectivity of the hippocampus-ACC pathway. Altered hippocampus-ACC connectivity may represent a highly salient intermediate neural phenotype for PTSD.<br><br>© 2016 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.22483
ID  - ref1
ER  -