TY  - JOUR
PY  - 2016//
TI  - Gabapentin concentrations and postmortem distribution
JO  - Forensic science international
A1  - Hamm, Catherine E.
A1  - Gary, Ray D.
A1  - McIntyre, Iain M.
SP  - 201
EP  - 203
VL  - 262
IS  - 
N2  - Gabapentin is a widely prescribed medication used primarily for the treatment of epilepsy and neuropathic pain. Gabapentin has a favorable adverse effect profile in therapeutic dosing with the most common reported effects being dizziness, fatigue, drowsiness, weight gain, and peripheral edema. Even with intentional self-poisonings, serious effects are generally rare. In this report, gabapentin analyses were performed on 30 postmortem cases that had peripheral blood, central blood and liver tissue. Overall the central to peripheral blood (C/P) ratio mean was 0.90±0.24 (mean±standard deviation), and a median of 0.97. The liver to peripheral blood (L/P) ratio mean was 0.68±0.26L/kg (mean±standard deviation), and a median of 0.65L/kg. An additional case, where both antemortem blood and postmortem peripheral blood specimens were available, revealed the same gabapentin concentration in both specimens. Taken together, the data presented suggests that gabapentin is unlikely to show postmortem redistribution.<br><br>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/j.forsciint.2016.03.028
ID  - ref1
ER  -